Merging Neuroscience & Technology
Applications for Neurovalens Technology
Type 2 Diabetes / ObesityPrimary Target:
Central Melanocortin System (CMCS) & Arcuate Nucleus (Hypothalamus)Secondary Target:
Dorsal Motor Nucleus of Vagus & Nucleus of the Solitary Tract (Brainstem)
Our goal in type 2 diabetes is to improve glucose and insulin regulation and therefore positively influence HbA1c. Optimization of the central melanocortin system and regulation of the vagal nerve afferents are the primary target areas to allow better glycemic control and potentially reduce the need for pharmaceuticals. Poor regulation of metabolic homeostasis drives the development of obesity. Neurovalens targets key hypothalamic and brainstem nuclei involved in the neuro-regulation of body composition, with the aim of improving this dysregulation at source.
Suprachiasmatic Nucleus (SCN) (Hypothalamus)Secondary Target:
Intergeniculate Leaflet (IGL) (Thalamus)
Homeostatic centers within the hypothalamus and thalamus regulate the circadian rhythm the and sleep wake cycle. Neurovalens’ technology actively stimulates the SCN and IGL in a way that improves both sleep quality and duration.
Locus Coeruleus (LC) (Brainstem)Secondary Target:
Paraventricular Nucleus (PVN) (Hypothalamus)
Regulation of the parasympathetic and sympathetic pathways of the autonomic nervous system in response to stress can be influenced via the LC and the PVN. Connections to these centers via the medial vestibular nucleus allow both to be non-invasively targeted.
Neuron pathway under Neurovalens Technology
The arcuate nucleus (ARC) of the hypothalamus is particularly regarded as a critical platform that integrates circulating signals of hunger and satiety reflecting energy stores and nutrient availability.
Central Melanocortin System
The central melanocortin system is a fascinating collection of neural circuits that provides an ideal neuroanatomical substrate for the integration of long-term adipostatic signals from leptin with acute hunger and satiety signals from vagal afferent activity, gut satiety and hunger peptides, and nutrients
The nucleus tractus solitarii (NTS) is the primary integrative center for cardiovascular control and other autonomic functions in the central nervous system (CNS).
Brown Adipose Tissue
Brown fat, also called brown adipose tissue, is a special type of body fat that is turned on (activated) when you get cold. Brown fat produces heat to help maintain your body temperature in cold conditions.
White Adipose Tissue
The traditional role attributed to white adipose tissue is energy storage, fatty acids being released when fuel is required. The metabolic role of white fat is, however, complex. For example, the tissue is needed for normal glucose homeostasis and a role in inflammatory processes has been proposed.
Muscle Sympathetic Nerve Activity
Muscle sympathetic nerve activity (MSNA), usually measured at the peroneal nerve, induces vasoconstriction, and is modulated by the baroreflex. MSNA also increases in response to hypoxic and hypercapnic chemoreceptor stimulation.
Glucose metabolism is the process where we eat carbohydrates, they breakdown into simple sugars which all turn into glucose which flows through the blood to the cells. Once the amount of glucose builds up around the cells, the pancreas get a signal to produce insulin.
The IGL, a known contributor to circadian rhythm regulation.
It's hypothesized that a primary role of orexins is to control sleep and arousal, and the neurons that release orexins are most active during the day.
The tiny suprachiasmatic nucleus (SCN) of the hypothalamus plays a central role in the daily programming of organismic functions by regulating day-to-day oscillations of the internal milieu and synchronizing them to the changing cycles of day and night and of body state.
What are your circadian rhythms? Your sleep-wake circadian rhythm is an internal clock that runs constantly, cycling between alertness and sleepiness.
The primary function of the locus coeruleus is to regulate the amount of noradrenaline in the forebrain. Thus, at a behavioral or systems level, the function of the locus coeruleus critically depends upon the dynamic interaction between the released noradrenaline and neuronal activity in its multiple target areas.
The paraventricular nucleus of the hypothalamus (PVN) is critical for the regulation of homeostatic function. ... Neurones from the PVN project to and can alter the function of sympathetic control regions in the medulla and spinal cord.
The amygdala is commonly thought to form the core of a neural system for processing fearful and threatening stimuli, including detection of threat and activation of appropriate fear-related behaviors in response to threatening or dangerous stimuli.
The limbic system functions to facilitate memory storage and retrieval, establish emotional states, and link the conscious, intellectual functions of the cerebral cortex with the unconscious, autonomic functions of the brain stem.
The sympathetic nervous system directs the body's rapid involuntary response to dangerous or stressful situations. A flash flood of hormones boosts the body's alertness and heart rate, sending extra blood to the muscles.
How Our Technology Works
Neurovalens is a global health-tech company that creates non-invasive neurostimulation technology used to treat a range of metabolic and neurological diseases.
Our core value is based on improving the lives of our patients, and is hinged on the generation of robust clinical data that clearly demonstrates meaningful safety and efficacy outcomes.
Our current focus is to provide drug-free treatments within four key health epidemics:
- Type 2 Diabetes
What is neuro stimulation?
Your brain consists of a vast network of almost 86 billion neurons that use a complex array of electrical signals to function properly, to communicate with each other, and to influence the regulation of the entire human body.
Improving these electrical processes has long been the goal of many well-known medical treatments, however, this has traditionally been limited to drugs that were designed to modify how the electrical connections between each neuron function.
Advances in medical technology now allow these electrical signals to be directly influenced without the need for medication.
Using electronic technology to influence and improve the brain is a process known as neurostimulation. As many neurostimulation devices are non-invasive, this offers a low-risk and drug-free approach to improving health issues that originate within the brain.
How does Neurovalens use neuro stimulation within its technology?
Neurovalens has created a non-invasive method of stimulating key areas of the brain and nervous system, and has developed this technology into a range of easy-to-use, wearable devices that deliver the required stimulation in the comfort of your own home.
The key target areas for Neurovalens’ technology are the hypothalamus and the associated autonomic nuclei of the brainstem. These areas are responsible for metabolic control, stress response and circadian regulation.
Our Vestal range of devices was designed to target metabolic disease, such as Type 2 Diabetes, Obesity and Pre-Diabetes.
Our Modius range of devices was designed to target neurological disease such as Insomnia, Anxiety & PTSD
How does Neurovalens technology influence the hypothalamus without being an implanted device?
The regulation of metabolic processes, such as glucose utilization or fat storage, is primarily regulated by the hypothalamus. As the location of the hypothalamus is deep within the brain, it has previously been very difficult to improve the performance of hypothalamic neurons using non-invasive neurostimulation.
Neurovalens technology overcomes this problem by using the known neural pathways from the surface of the head, through the brainstem and into the hypothalamus.
Specifically, as we know that the peripheral nerve fibres of CN VIII terminate in the mastoid area behind each ear, we can apply neurostimulation through the skin and activate the nerves non-invasively. This signal is carried to the Medial vestibular Nucleus in the brainstem, and then proceeds to a network of autonomic nuclei and also to the hypothalamus.
With this method, the Neurovalens technology can safely and consistently activate neurons in the hypothalamus in an entirely non-invasive and drug-free way.